منابع مشابه
Recent changes in biological availability of digoxin. Effect of an alteration in 'Lanoxin' tablets.
Steady-state digoxin levels were recorded in patients using 'Lanoxin' (Burroughs Wellcome) tablets made before and after the recent change in the manufacture of this brand of digoxin tablet. Levels obtained with the newer Lanoxin tablets were two-thirds higher than those recorded with tablets produced before the change in manufacture. The biological availability of the most commonly used other ...
متن کاملBiological availability of digoxin from Lanoxin produced in the United Kingdom.
Though established quality control standards were maintained, the bioavailability of digoxin from Lanoxin tablets produced in the United Kingdom fell in 1969, and was restored in 1972. After 1.5 mg doses of representative batches, tablets made between 1969 and 1972 produced mean values for area under the 50 hours plasma concentration/time curve of 36.6 ng/ml/hr and four-day urinary excretion of...
متن کاملDigoxin immunoassay with cross-reactivity of digoxin metabolites proportional to their biological activity.
Our objective was to identify commercially available digoxin immunoassays whose cross-reactivity with digoxin metabolites paralleled the pharmacological activity of the metabolites. We measured the immunoreactivity of digoxigenin bis- and monodigitoxosides, digoxigenin, and dihydrodigoxin in four immunoassays and compared the immunoactivities with pharmacological activities from studies involvi...
متن کاملAssessment of Abnormal Serum Digoxin Concentration
ABSTRACT Cardiac glycosides have been used in the management of heart failure for more than 200 years and remain the only drug currently available for Long-term ambulatory use that have positive inotropic effect. The relatively narrow therapeutic- index of cardiac glycosides renders them particularly difficult to use, and the clinician should have a detailed understanding of the actions and ph...
متن کاملAerobic and Anaerobic Incubation — Biological Indexes of Soil Nitrogen Availability
Our researches have been made on brown forest soil that had been used in long-term experiments set up according to specified fertilization system for over 30 years. We have chosen those experiment variants in which quantities of nitrogen fertilizers were gradually increased. The soil samples taken from 0 cm to 30 cm depth were used to determine biological indexes of nitrogen availability (aerob...
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ژورنال
عنوان ژورنال: BMJ
سال: 1973
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5859.177-b